The incidence of metabolic syndrome in psoriasis patients and its correlation with disease activity: a systematic review and meta-analysis

作者：Zongyang Li, Zheng Gu, Jingyu Xiang, Xiaoyan Zhang · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1593003 · 被引用次数：8 · 研究领域：Psoriasis: Treatment and Pathogenesis、Skin Diseases and Diabetes、Spondyloarthritis Studies and Treatments

Objective To explore the association between psoriasis and metabolic syndrome (MetS) and analyze the impact of disease activity on the risk of MetS occurrence. Method This systematic review and meta-analysis used computer searches to search for relevant literature on psoriasis and MetS in databases including China National Knowledge Infrastructure (CNKI), PubMed, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase. The search period was from the establishment of the database to February 8, 2025. Inclusion in case–control, cohort studies and cross-sectional, with language restrictions in Chinese and English during retrieval. After independent screening of literature, extraction of data, and evaluation of risk bias for inclusion in the study by two evaluators, meta-analysis and subgroup analysis were conducted using Stata17.0 software. Result A total of 12 studies were analyzed, encompassing 9,641 patients with psoriasis and 2,554 patients suffering from MetS alongside psoriasis. The incidence of metabolic syndrome in psoriasis patients was analyzed and the combined effect size was 26.49% [95% CI (25.61, 27.39%)]. Results from the meta-analysis indicated that, in comparison to the control group, psoriasis patients demonstrated a heightened risk of developing MetS [OR = 1.27, 95% CI (1.21–1.33), p < 0.001]. Subgroup analysis revealed that patients with severe psoriasis (PASI≥10) had a significantly increased risk of developing metabolic syn...