Long-term trials of colchicine for secondary prevention of vascular events: a meta-analysis

作者：Michelle Samuel, Colin Berry, Marie‐Pierre Dubé, Wolfgang Köenig, José López‐Sendón, Aldo P. Maggioni, Fausto J. Pinto, François Roubille, Jean‐Claude Tardif · 发表于：European Heart Journal · 年份：2025 · DOI：10.1093/eurheartj/ehaf174 · 被引用次数：66 · 研究领域：Inflammasome and immune disorders、Biomarkers in Disease Mechanisms、Gout, Hyperuricemia, Uric Acid

BACKGROUND AND AIMS: Colchicine has emerged as a safe and inexpensive anti-inflammatory medication to target the residual risk of cardiovascular events in the secondary prevention of coronary artery disease. Two recently published randomized controlled trials (RCTs) investigating colchicine in the post-stroke and post-myocardial infarction (MI) populations warrant a re-evaluation of colchicine. New evidence was synthesized in a systematic review and meta-analysis to determine the long-term efficacy and safety of colchicine for the secondary prevention of vascular disease. METHODS: Randomized controlled trials comparing the incidence of cardiovascular events between patients with clinically manifest vascular disease randomized to colchicine vs. placebo and ≥12-month follow-up were included. The primary efficacy endpoint is major adverse cardiovascular events (MACE) and includes cardiovascular mortality, MI, ischaemic stroke, and urgent coronary revascularization. The DerSimonian and Laird random effects model was used to calculate pooled effect estimates. RESULTS: Six RCTs, with a pooled sample size of 21 800 patients, were included (colchicine n = 10 871; placebo n = 10 929). Over a follow-up of 12-34 months, colchicine reduced the incidence of MACE compared with placebo [pooled hazard ratio .75, 95% confidence interval (CI) .56-.93]. The reduction in cardiovascular events among colchicine patients was driven by reductions in MIs, ischaemic strokes, and urgent coronary revasc...