Modular Assembly of Axially Chiral QUINAP Derivatives via Nickel-Catalyzed Enantioselective C–P Cross-Coupling

作者：Zhiping Yang, Xiaodong Gu, Li‐Biao Han, Jun Wang · 发表于：ACS Catalysis · 年份：2025 · DOI：10.1021/acscatal.5c01663 · 被引用次数：20 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Molecular spectroscopy and chirality、Alkaloids: synthesis and pharmacology

QUINAPs represent a powerful class of ligands with broad applications in a diverse array of synthetically important asymmetric transformations. However, their broader utilization is often constrained by a limited substrate scope and high cost associated with their multistep synthesis. Consequently, a highly efficient dynamic kinetic asymmetric transformation of N -heterobiaryl derivatives has been developed through Ni-catalyzed asymmetric C–P cross-coupling. This method provides versatile access to a wide range of substituted QUINAP derivatives with good yields and high enantioselectivities, which are successfully applied in both transition-metal catalysis and organocatalysis.