Transfer of AuNRs into AAO Nanoholes via Self-Assembly Method for Ultrasensitive SERS Detection

作者：Ziqing Fang, Jun Dong, Yimeng Fan, Chenlu Li, Qingyan Han, Chengyun Zhang, Lipeng Zhu, Xuewen Yan, Jianxia Qi, Wei Gao · 发表于：ACS Omega · 年份：2025 · DOI：10.1021/acsomega.5c00417 · 被引用次数：3 · 研究领域：Gold and Silver Nanoparticles Synthesis and Applications、Advanced biosensing and bioanalysis techniques、Advanced Nanomaterials in Catalysis

High Resolution Image Download MS PowerPoint Slide Surface-enhanced Raman scattering (SERS) has become an advanced spectroscopic analysis method in the fields of chemistry, biomedical sensing, and imaging, owing to its excellent vibrational signal recognition and sensitivity for single-molecule detection. The effectiveness of SERS technology relies on the development of high-performance substrates, which must possess high sensitivity, uniformity, and repeatability. In this study, the enhanced substrates with high Raman activity were successfully prepared by adopting the three-phase self-assembly method to assemble gold nanorods (AuNRs) into nanopores of ultrathin porous alumina (AAO) films. By precisely controlling the pore size of AAO and the dimensions of AuNRs, the ability of the substrates and the Raman detection limits are enhanced significantly. Probe molecules, including Rhodamine 6G (R6G), Crystal Violet (CV), and Aspartame (APM), were selected to test the substrates sensitivity and uniformity, with detection limits of 10 –13, 10 –12 M, and 7.8 mg/L, respectively. Random sampling was conducted on the substrate surface to analyze the spectral characteristics of the characteristic peaks of R6G and CV molecules, and the relative standard deviations (RSD) were 4.3 and 3.18% at characteristic peaks 612 and 1619 cm –1, respectively, demonstrating the enhanced uniformity of the prepared substrates. This research indicates that assembling AuNRs onto AAO substrates results in ...