Global evolution of inflammatory bowel disease across epidemiologic stages

作者：Lindsay Hracs, Joseph W. Windsor, Julia Gorospe, Michael Cummings, Stephanie B. Coward, Michael J. Buie, Joshua Quan, Quinn Goddard, Léa Caplan, Ante Markovinović, Tyler S. Williamson, Yvonne Abbey, Murdani Abdullah, María T. Abreu, Vineet Ahuja, Raja Affendi Raja Ali, Mansour A. Altuwaijri, Domingo Cesar Balderramo, Rupa Banerjee, Eric I. Benchimol, Charles Noah Bernstein, Eduard Brunet, Johan M. Burisch, Vui Heng Chong, Iris Dotan, Usha Dutta, Sara El Ouali, Angela J. Forbes, Anders Forss, Richard Blair Gearry, Hang Viet Dao, Juanda Leo Hartono, Ida Normiha Hilmi, Phoebe Hodges, Gareth‐Rhys Jones, Fabián Juliao Baños, Jamilya A. Kaibullayeva, Paul M. Kelly, Taku Kobayashi, Paulo Gustavo Kotze, Peter Laszlo Lakatos, Charlie W. Lees, Julajak Limsrivilai, Bobby Zhao Sheng Lo, Edward V. Loftus, Jonas Filip Ludvigsson, Joyce Wing Yan Mak, Yinglei Miao, Ka Kei Ng, Shinji Okabayashi, Ola Olén, Remo Panaccione, Mukesh Sharma Paudel, Abel Botelho Quaresma, David T. Rubin, Marcellus Simadibrata, Yang Sun, Hidekazu Suzuki, Martín Toro, Dan Turner, Beatriz Iade, Shu‐Chen Wei, Jesús K. Yamamoto‐Furusho, Suk‐Kyun Yang, Siew C. Ng, Gilaad G. Kaplan · 发表于：Nature · 年份：2025 · DOI：10.1038/s41586-025-08940-0 · 被引用次数：441 · 研究领域：Inflammatory Bowel Disease、Eosinophilic Esophagitis、Healthcare Systems and Reforms

During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania1. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin America, while the prevalence in early industrialized regions continued to grow steadily2–4. Changes in the incidence and prevalence denote the evolution of IBD across four epidemiologic stages: stage 1 (emergence), characterized by low incidence and prevalence; stage 2 (acceleration in incidence), marked by rapidly rising incidence and low prevalence; and stage 3 (compounding prevalence), where the incidence decelerates, plateaus or declines while the prevalence steadily increases. A fourth stage (prevalence equilibrium) has been proposed in which the prevalence slope plateaus due to demographic shifts in an ageing IBD population, but it has not yet been evidenced. To date, these stages have remained theoretical, lacking specific numerical indicators to define transition points. Here, using real-world data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024), we show spatiotemporal transitions across stages 1–3 and model stage 4 progression. Understanding the evolution of IBD across epidemiologic stages enables healthcare systems to better anticipate the future worldwide burden of IBD. An analysis of data from 522 population-base...