Characteristics and risk factors for outcomes in patients with Mycoplasma pneumoniae mono- and coinfections: A multicenter surveillance study in Wuhan, China, 2023

作者：Banghua Chen, Jie Pan, Ying Peng, Yuanyuan Zhang, Yi Wan, Hongjie Wei, Kangguo Li, Wentao Song, Yunkang Zhao, Kang Fang, Huiming Ye, Jiali Cao, Jia Rui, Zeyu Zhao, Tianmu Chen · 发表于：Infectious Disease Modelling · 年份：2025 · DOI：10.1016/j.idm.2025.04.006 · 被引用次数：3 · 研究领域：Pneumonia and Respiratory Infections、Respiratory viral infections research、Immune responses and vaccinations

Objectives: (MP) is a key cause of community-acquired pneumonia, and coinfections lead to varied patient outcomes. A comprehensive understanding of the outcome characteristics and associated etiologies of coinfections in MP patients is lacking. Methods and results: -severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A-parainfluenza virus (PIV) or adenovirus-PIV. Logistic regression analysis demonstrated that male sex and adult age (particularly ≥40 years) were significantly associated with adverse outcomes in MP monoinfection. For coinfections, significantly higher hospitalization rates were reported among very young children (0-5 years) and adults aged ≥40 years, whereas adults presented an increased risk of severe disease. Coinfection outcomes were significantly associated with seasons of the year (winter, spring, and summer), specific age groups (3-5 years, 18-39 years, 40-50 years, and 60 years and over), gender (male), and longer onset-to-diagnosis periods. Middle-aged and elderly patients, coinfection, spring and summer, gender (male), and longer onset-to-diagnosis periods were significantly associated with increased hospitalization and serious illness risk. Coinfection, winter, older (adult) age, and gender (male) were significantly associated with an increased risk of death. Conclusions: Compared with adults, children with MP have a greater morbidity risk, whereas middle-aged and older adults face greater risks of hospitalization, serious illness,...