Stability of alveolar ridge following horizontal guided bone regeneration after implant loading for 1 -2 years: a retrospective comparative study

作者：Zhaoxia Jiang, Dejing Kong, Chuanqing Zhou, Yixin Liang, Mingli Liu, Zhe Qu · 发表于：BMC Oral Health · 年份：2025 · DOI：10.1186/s12903-025-06025-y · 被引用次数：5 · 研究领域：Dental Implant Techniques and Outcomes、Periodontal Regeneration and Treatments、Bone Tissue Engineering Materials

OBJECTIVE: This retrospective comparative study aimed to evaluate the effects of guided bone regeneration(GBR) on horizontal bone augmentation of the alveolar ridge in the mandibular posterior region and bone stability after loading for 1-2 years. We measured and analyzed the changes in alveolar ridge bone width to observe the clinical effect of bone grafting. The RANK/RANKL/OPG concentration in gingival crevicular fluid around the implant was quantitatively analyzed and compared with that of healthy natural teeth to assess the bone condition. METHODS: Fifty-two patients admitted to the Department of Implantology of Dalian Stomatological Hospital were selected. 22 implanted dentures of 22 patients that were repaired with soft tissue-level implants after horizontal bone grafting (experimental group). Thirty patients had 30 implanted dentures with the same system of implants without bone grafting (control group). The gingival crevicular fluid around the implant and healthy control natural teeth were collected via the same filter paper strip after loading for 1-2 years. The concentrations and ratios of RANKL and OPG were quantitatively detected via ELISA. The CBCT images taken before bone grafting, on the day after surgery, 6 months after surgery, and after loading were superimposed to measure the horizontal width of the alveolar ridge. Measurements were taken 2 mm apical from the top of the crest at the center of the implant. RESULTS: The average alveolar crest width in the exp...