Investigation of the association between the triglyceride-glucose index and the incidence of frailty among middle-aged and older adults: evidence from the China health and retirement longitudinal study

作者：Qingwen Long, Yongli Li, Zijuan Shi, Yujun Lee, Lifang Mao · 发表于：Frontiers in Public Health · 年份：2025 · DOI：10.3389/fpubh.2025.1548222 · 被引用次数：5 · 研究领域：Frailty in Older Adults、Nutrition and Health in Aging、Chronic Disease Management Strategies

Aim Limited researches have investigated the association between the Triglyceride-glucose index (TyG) and frailty vulnerability in middle-aged and older Chinese populations. This study aims to strengthen the scientific foundation for frailty prevention and management by analyzing the correlation between TyG and frailty, ultimately providing more targeted intervention strategies. Methods This study included middle-aged and older individuals who participated in the China Health and Retirement Longitudinal Study (CHARLS) from 2015. A multiple logistic regression model was constructed to assess the correlation between the TyG index and frailty. Additionally, restricted cubic spline (RCS) analysis was employed to evaluate the dose–response correlation between the two variables. Results Among the 3,978 participants included in the study, 667 individuals (16.8%) were identified with frailty. After adjusting for multiple factors in a logistic regression model, it was determined that individuals in the highest quartile group of the TyG index had a 1.43 times higher risk of frailty compared to those in the lowest quartile group (OR = 1.43, 95% CI: 1.10 ~ 1.85, p = 0.007). The RCS analysis further revealed a positive dose–response relationship, indicating that a higher TyG index was associated with an increased risk of frailty in middle-aged and older adults. Conclusion Research has shown a significant positive linear relationship between an increased TyG index and a higher prevalence o...