The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites

作者：Yue Dong, Sin Man Lam, Yan Li, Min‐Dian Li, Guanghou Shui · 发表于：Journal of genetics and genomics/Journal of Genetics and Genomics · 年份：2025 · DOI：10.1016/j.jgg.2025.04.014 · 被引用次数：15 · 研究领域：Circadian rhythm and melatonin、Dietary Effects on Health、Genetics, Aging, and Longevity in Model Organisms

The circadian clock is a highly hierarchical network of endogenous pacemakers that primarily maintains and directs oscillations through transcriptional and translational feedback loops, which modulates an approximately 24-h cycle of endocrine and metabolic rhythms within cells and tissues. While circadian clocks regulate metabolic processes and related physiology, emerging evidence indicates that metabolism and circadian rhythm are intimately intertwined. In this review, we highlight the concept of metabolites, including lipids and other polar metabolites generated from intestinal microbial metabolism and nutrient intake, as time cues that drive changes in circadian rhythms, which in turn influence metabolism and aging. Furthermore, we discuss the roles of functional metabolites as circadian cues, paving a new direction on potential intervention targets of circadian disruption, pathological aging, as well as metabolic diseases that are clinically important.