Construction of planar chiral [2,2]paracyclophanes via photoinduced cobalt-catalyzed desymmetric addition

作者：Shiqi Liu, Wei Xiong, Ji-Chao Huang, Xuan‐Feng Jiang, Wenhan Xu, Zhihan Zhang, Ying Cheng, Liang‐Qiu Lu, Ke Gao, Wen‐Jing Xiao · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-59089-3 · 被引用次数：18 · 研究领域：Synthesis and Properties of Aromatic Compounds、Radical Photochemical Reactions、Axial and Atropisomeric Chirality Synthesis

Planar chiral [2,2]paracyclophanes (PCPs) are widely used in materials science and asymmetric syntheses. Therefore, synthetic and material chemists have focused on the efficient and selective construction of planar chiral PCPs for decades. Herein, we present a photoinduced cobalt-catalyzed desymmetric addition of pseudo-para-diformyl and pseudo-gem-diformyl PCP, enabling the synthesis of planar chiral PCP alcohols with both planar and central chiralities. This method delivers 48 examples with yields up to 87%, diastereomeric ratios greater than 19:1, and an enantiomeric excess exceeding 99%. This protocol provides a original and efficient approach for the synthesis of planar chiral PCPs. Planar chiral [2,2]paracyclophanes (PCPs) are widely used in materials science and asymmetric syntheses. Here the authors present a cobalt-catalyzed desymmetric addition of pseudopara-diformyl and pseudo-gem-diformyl PCPs, enabling the synthesis of planar chiral PCP alcohols with both planar and central chiralities.