Maternal Hypertension and Adverse Neurodevelopment in a Cohort of Preterm Infants

作者：Shipra Jain, Ting Ting Fu, Maria E. Barnes‐Davis, Rashmi D. Sahay, Shelley R. Ehrlich, Chunyan Liu, Mounira Habli, Nehal A. Parikh, Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Investigators, Priyanka VSP Illapani, Karen Harpster, Beth M. Kline‐Fath, Hailong Li, Lili He, Stephanie L. Merhar, Jean A. Tkach, Hui Wang · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.7788 · 被引用次数：11 · 研究领域：Pregnancy and preeclampsia studies、Neonatal and fetal brain pathology、Maternal Mental Health During Pregnancy and Postpartum

Importance: Whether maternal hypertensive disorders of pregnancy (HDP) confer independent neurodevelopmental deficit risks in premature infants is controversial. Previous studies are limited by inadequate confounding variable control and other biases. Objective: To evaluate the associations between maternal HDP, especially preeclampsia, and neurodevelopmental outcomes of preterm infants at 2 years' corrected age. Design, Setting, and Participants: Regional prospective cohort study of 395 preterm infants (≤32 weeks' gestation) from 5 level III and IV southeast Ohio neonatal intensive care units from September 2016 to November 2019. Data analysis was conducted in August 2022. Exposure: HDP, defined by maternal diagnosis of chronic or gestational hypertension or preeclampsia during pregnancy. Main Outcomes and Measures: Structural brain magnetic resonance imaging was performed at term-equivalent age. Neurodevelopment was assessed by Bayley Scales of Infant and Toddler Development (BSID), Third Edition, between 22 and 26 months' corrected age. Multivariable regression was used to identify the independent association of HDP and preeclampsia on cognitive (primary outcome), language, and motor development, controlling for several confounders. Mediation analyses were performed to understand if the association with HDP was mediated by its association with birth weight or brain abnormalities. Results: In a cohort of 395 infants, the median (IQR) gestational age was 29.6 (27.6-31.4) wee...