Transjugular diagnostic procedures in hepatology: Indications, techniques and interpretation

作者：Dominik Bettinger, Annalisa Berzigotti, Mattias Mandorfer, Cristina Ripoll, Christian Labenz, Eugen Zizer, Tony Bruns, Andrea De Gottardi, J. Emrich, Cornelius Engelmann, Benjamin Maasoumy, Arnulf Ferlitsch, Valentin Fuhrmann, Jan B. Hinrichs, Christian Jansen, Carolin Lackner, Robert Matzberger, Carsten Meyer, Behrang Mozayani, Michael Praktiknjo, Philipp A. Reuken, Michael Schultheiß, Alexander Zipprich, Christian M. Lange, Roman Kloeckner, Christoph Sarrazin, Jonel Trebicka, Thomas Reiberger, Jaime Bosch, Matthias Dollinger · 发表于：JHEP Reports · 年份：2025 · DOI：10.1016/j.jhepr.2025.101437 · 被引用次数：14 · 研究领域：Liver Disease and Transplantation、Liver Disease Diagnosis and Treatment、Organ Transplantation Techniques and Outcomes

Measurement of the hepatic venous pressure gradient (HVPG) and transjugular liver biopsy have emerged as important tools in clinical hepatology. Measurement of HVPG is considered the gold standard for detecting clinically significant portal hypertension, with an HVPG of ≥10 mmHg being the key prognostic threshold in patients with compensated advanced chronic liver disease (cACLD; compensated cirrhosis). A transjugular liver biopsy can be obtained within the same procedure and may be preferred over percutaneous liver biopsy in patients with coagulopathy, ascites and/or significant obesity. Endoscopic ultrasound-guided procedures are currently under investigation and require standardisation. This article summarises critical technical aspects of HVPG measurements and transjugular liver biopsy and provides a detailed overview of their current role in the context of emerging non-invasive tests and endoscopic approaches.