Whole-cerebrum three-dimensional pseudo-continuous arterial spin labeling at 5T: reproducibility and preliminary application in moyamoya

作者：Xiaoyuan Fan, Zhonghui Li, Guangsong Han, Gan Sun, Hualu Han, Yuehui Hong, Shuo Chen, Hui You, Jun Ni, Guobin Li, Mingli Li, Feng Feng · 发表于：Quantitative Imaging in Medicine and Surgery · 年份：2025 · DOI：10.21037/qims-24-2274 · 被引用次数：2 · 研究领域：Advanced MRI Techniques and Applications、Lanthanide and Transition Metal Complexes、Cerebrovascular and Carotid Artery Diseases

Background: Pseudo-continuous arterial spin labeling (PCASL) at 7T benefits from increased signal-to-noise ratio (SNR) and prolonged T1, but suffers from field inhomogeneities and increased specific absorption rate (SAR). We proposed that 5T magnetic resonance imaging (MRI) system may be a balanced choice for PCASL imaging. The aim of this study was to achieve whole-cerebrum PCASL imaging at ultra-high field 5T MRI system, assess the reproducibility and preliminarily explore its clinical application in moyamoya disease/syndrome. Methods: Twenty healthy volunteers were prospectively recruited for the reproducibility analysis. Both single-delay and multi-delay PCASL sequences were scanned twice on the 5T MRI scanner separated by a 10-minute period. Uncorrected cerebral blood flow (uCBF) from single-delay arterial spin labeling (ASL), corrected cerebral blood flow (cCBF) and arterial transit time (ATT) from multi-delay ASL were computed. The reproducibility of uCBF, cCBF and ATT were evaluated by calculating intraclass correlation coefficient (ICC), within-subject coefficient of variation (wsCV) and Pearson correlation coefficients between twice scans in grey matter regions and white matter (WM). Also, 26 patients diagnosed with moyamoya disease/syndrome were included and underwent multi-delay PCASL. The severity of intracranial arteries was graded as magnetic resonance angiography (MRA) score using time-of-flight (TOF) MRA. The relationship between MRA score and cCBF/ATT were a...