Association between neutrophil-percentage-to-albumin ratio and periodontitis: insights from a population-based study

作者：Ziyang Zheng, Xinyu Xie, Lan Wang, Mingzhang Xu, Jingjing He, Yunyi Deng, Ke Yu · 发表于：Frontiers in Nutrition · 年份：2025 · DOI：10.3389/fnut.2025.1551349 · 被引用次数：2 · 研究领域：Oral microbiology and periodontitis research、Inflammatory Biomarkers in Disease Prognosis、Oral and gingival health research

Background Periodontal diseases, characterized by the loss of tooth-supporting structures, are highly prevalent in the general population. The Neutrophil-Percentage-To-Albumin Ratio (NPAR) has been identified as a promising biomarker for systemic inflammation, but its relationship with periodontal disease has not been thoroughly investigated. Despite growing interest in its role in other chronic conditions, the specific connection between NPAR and periodontal disease remains underexplored and requires further examination to understand its potential clinical applications. Methods A population-based analysis was performed using data from the National Health and Nutrition Examination Survey (NHANES), with a total of 8,389 participants included with complete full-mouth periodontal examination, NPAR related index and covariates. NPAR was employed as the primary independent variable, the periodontitis and clinical periodontal parameters were set to the outcomes along with tooth counts and functional dentition as the sensitivity outcomes. To investigate its association between NPAR and periodontitis, weighted multivariate linear and logistic regression analyses were conducted. Sensitivity and replication analyses were also carried out to assess the robustness and reliability of the findings. Results This population-based study revealed a significant association between elevated NPAR levels and a higher likelihood of periodontitis, increased attachment loss (AL), and probing depth (P...