The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment,

作者：The Working Group on the update of the ESHRE/ALPHA Istanbul Consensus, Giovanni Coticchio, Aisling Ahlström, Gemma Arroyo, Başak Balaban, Alison Campbell, María José de los Santos, Thomas Ebner, David K. Gardner, Borut Kovačič, Kersti Lundin, M. Cristina Magli, Saria Mcheik, Dean E. Morbeck, Laura Francesca Rienzi, Ioannis A. Sfontouris, Nathalie Vermeulen, Mina Alikani, Giovanni Coticchio, Aisling Ahlström, Gemma Arroyo, Başak Balaban, Alison Campbell, María José de los Santos, Thomas Ebner, David K. Gardner, Borut Kovačič, Kersti Lundin, M. Cristina Magli, Saria Mcheik, Dean E. Morbeck, Laura Francesca Rienzi, Ioannis A. Sfontouris, Nathalie Vermeulen, Mina Alikani · 发表于：Human Reproduction · 年份：2025 · DOI：10.1093/humrep/deaf021 · 被引用次数：68 · 研究领域：Reproductive Biology and Fertility、Ovarian function and disorders、Prenatal Screening and Diagnostics

STUDY QUESTION: What are the current recommended criteria for morphological assessment of oocytes, zygotes, and embryos? SUMMARY ANSWER: The present ESHRE/Alpha Scientists in Reproductive Medicine consensus document provides several novel recommendations to assess oocyte and embryo morphology and rank embryos for transfer. WHAT IS KNOWN ALREADY: A previous Alpha Scientists in Reproductive Medicine/ESHRE consensus on oocyte and embryo morphological assessment was published in 2011. After more than a decade, and the integration of time-lapse technology into embryo culture and assessment, a thorough review and update was needed. STUDY DESIGN, SIZE, DURATION: A working group consisting of Alpha Scientists in Reproductive Medicine executive committee members and ESHRE Special interest group of Embryology members formulated recommendations on oocyte and embryo assessment. PARTICIPANTS/MATERIALS, SETTING, METHODS: The working group included 17 internationally recognized experts with extensive experience in clinical embryology. Seven members represented Alpha Scientists in Reproductive Medicine and eight members represented ESHRE, along with to two methodological experts from the ESHRE central office. Based on a systematic literature search and discussion of existing evidence, the recommendations of the Istanbul Consensus (2011) were reassessed and, where appropriate, updated based on consensus within the working group. A stakeholder review was organized after the updated draft was f...