Effects of singing on vascular health in older adults with coronary artery disease: a randomized, crossover trial

作者：Mehri Bagherimohamadipour, Muhammad Hammad, Alexis Visotcky, Rodney Sparapani, Jacquelyn Kulinski · 发表于：Frontiers in Cardiovascular Medicine · 年份：2025 · DOI：10.3389/fcvm.2025.1546462 · 被引用次数：3 · 研究领域：Music Therapy and Health、Neuroscience and Music Perception、Voice and Speech Disorders

Background The impact of singing on cardiovascular health has not been extensively studied. The aim of this study is to investigate the effect of singing on cardiovascular biomarkers in an aging population with coronary artery disease (CAD). Methods Participants had three study visits separated by 2–7 days, according to a randomized, researcher-blinded, crossover, controlled design: (1) a 30-min period of live singing with an in-person music therapist, (2) a 30-min period of singing along to an instructional video and (3) a 30-min rest (control). Primary outcomes included macrovascular endothelial function assessed by brachial artery flow-mediated dilation and microvascular function assessed by peripheral arterial tonometry [Framingham reactive hyperemia index (fRHI) and reactive hyperemia index (RHI)]. Heart rate variability (HRV) was a secondary outcome. Results Sixty-five subjects (mean age 67.7 ± 0.8 years, 40% female) completed the study. Compared to control, there was an increase in fRHI for the singing video intervention (estimate: 0.54, SE: 0.19, p = 0.005) but not for the live singing intervention (estimate: 0.11, SE: 0.18, p = 0.570). There was no change in macrovascular function with either intervention. The low frequency/high frequency (LF/HF) ratio increased by 2.80 (SE: 1.03, p = 0.008), and the natural logarithm of high frequency (LnHF) power decreased by −0.90 ms 2 (SE: 0.29, p = 0.003) with the video (during to pre-change). When assessing post- to pre- change...