The role of macrophages in polycystic ovary syndrome: A review

作者：Li Li, Yubo Xiao, Wenwei Wen, Qi Liu, Wei Le, Pinyue Liu, Ming Li · 发表于：Medicine · 年份：2025 · DOI：10.1097/md.0000000000042228 · 被引用次数：3 · 研究领域：Endometriosis Research and Treatment、Ovarian function and disorders、Reproductive System and Pregnancy

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among fertile women, which is influenced by genetics and environment. A recent study revealed that PCOS patients were in a chronic inflammatory state, and they had abnormally activated macrophages. This paper introduces the relationship between PCOS and macrophages. The forkhead box protein O1 (FOXO-1), migration inhibitory factor, sympathetic conservation disorder, and vitamin D are believed to influence macrophages in PCOS. There is evidence that PCOS-associated abnormalities are associated with macrophages, including insulin resistance, obesity, hyperandrogenism (HA), hyperhomocysteinemia (HHcy), cardiometabolic disorder and gut microbiota dysbiosis. This review summarizes the research status of macrophages in PCOS. Macrophages might be a potential PCOS treatment candidate.