Epidemiology and disease burden of fractures in Asia, 1990–2021: An analysis for the Global Burden of Disease Study 2021

作者：Yechao Shen, Boren Tan, Jiahao Zhang, Ning Zhang, Zhan Wang · 发表于：Journal of Orthopaedic Translation · 年份：2025 · DOI：10.1016/j.jot.2025.04.001 · 被引用次数：10 · 研究领域：Bone health and osteoporosis research、Bone fractures and treatments、Hip and Femur Fractures

Background: Fractures are a significant global public health concern, imposing a substantial economic burden, particularly among the elderly. However, research on the fracture burden in Asia remains limited, highlighting the need for comprehensive and up-to-date studies to support the effective planning and allocation of healthcare resources across the region. Methods: Using the Global Burden of Disease (GBD) 2021 database, we analyzed the age-standardized rates (ASRs) of incidence (ASIR), prevalence (ASPR), and years lived with disability (YLDs) (ASYR) associated with fracture burden across Asia. Our study explored trends over time, variations by age, sex, and country, and examined the correlation between fracture burden and the sociodemographic index (SDI). Results: In 2021, fractures in Asia caused 91.3 million (95 % uncertainty interval, 83.65-99.47) incident cases, 232.71 million (95 % UI, (215.57-250.39) prevalent cases, and 12.97 million (95 % UI, 8.89-17.82) YLDs, with age-standardized rates of 1968.49 (95 % UI, 1799.15-2147.14) for incidence (ASIR), 4683.96 (95 % UI, 4347.58-5036.61) for prevalence (ASPR), and 261.72 (95 % UI, 179.43-358.94) for YLDs (ASYR) per 100,000 population. Despite a higher absolute burden, Asian age-standardized rates of fracture were slightly lower than the global average. For ASYR, the most burdensome fractures were those of the patella, tibia/fibula/ankle, hip, and pelvis. Between 1990 and 2021, fracture incident cases, prevalent cases, an...