Comparative study of brain functional imaging of brain in patients with mild to moderate Alzheimer’s disease based on functional near infrared spectroscopy

作者：Zhen Yang, Li Liu, Tao You, Lingling Wang, Yi Fang, Yu Jiang, Ying Zhou · 发表于：BMC Neurology · 年份：2025 · DOI：10.1186/s12883-024-03989-2 · 被引用次数：6 · 研究领域：Optical Imaging and Spectroscopy Techniques、Neurological Disease Mechanisms and Treatments、Infrared Thermography in Medicine

OBJECTIVE: Based on the near-infrared functional brain imaging system, this research studied the hemoglobin concentration signal in resting state and task state. The purpose of this research was to analyze the activated brain regions and functional connections by exploring the changes in hemoglobin concentration and the differences in brain network functional connections between healthy people and mild to moderate AD patients. So as to identify the cognitive dysfunction of patients at an early stage. By accurately locating the area of cognitive impairment in patients, it provides a basis for precise neural regulation of physical therapy. METHODS: Patients who came to our hospital from January 2022 to December 2022 were recruited and selected according to the exclusion criteria. After receiving their informed consent, MMSE scale examination and near-infrared brain function imaging examination were performed in a relatively quiet environment. RESULT: A total of 24 subjects were included in this study, including 7 in the control group (age: 72.57 ± 7.19) and 17 (age: 76.88 ± 9.29) in the AD group. The average cognitive scores were (28.00 ± 1.16), (19.24 ± 4.89), respectively. There were no statistically significant differences in gender, years of education, age, and past medical history between the AD group and the control group (P > 0.05). In the verbal fluency test (VFT) task, there was a significant difference in the activation values of the two groups in channels 01, 06, 07,...