Cohort Profile: Kunshan Aging Research with E-health (KARE)

作者：Tian Xie, Ying Pan, Lu Ke, Yinlin Wei, Fei Chen, Zijian Tian, Peng Wu, Qian Li, Benrui Wu, Yiying Liu, Jingnan Xue, Jie Bai, Wenming Dong, Yang Liu, J.F. Shao, Ying Chen, Xiaozhou Zhou, Yuxuan Du, Ziqing Liu, Sheng Gao, Yao Cheng, Rong Huang, Zhiqin Zhang, Yu-Shan Yue, Shao Zhong, Zhiyong Deng, Kaiyun Zhou, Kaiyun Zhou, Jian Jin, Chong Li, Tao Xu, Kaixin Zhou, Kaixin Zhou · 发表于：International Journal of Epidemiology · 年份：2025 · DOI：10.1093/ije/dyaf041 · 被引用次数：8 · 研究领域：Chronic Disease Management Strategies、Health disparities and outcomes、Cardiovascular Health and Risk Factors

The Kunshan Aging Research with E-health (KARE) cohort is a population-based, longitudinal study that follows 100 000 individuals aged ≥60 years who reside in Kunshan City, China (Fig. 1). KARE aims to facilitate research on ageing health, focusing on factors—including genetic, environmental, and their complex interactions—that influence the development, onset, progression, and treatment response of chronic diseases among the elderly. ... Population ageing is a significant demographic trend in China. In 2019, the number of people aged >60 years reached ∼256 million, accounting for 18.1% of the population. The proportion was projected to reach 40% by 2050 [1]. The provision of quality healthcare to this growing elderly population poses significant medical and economic challenges [2, 3]. This demographic shift underscores the need for comprehensive strategies to address the rising prevalence of age-related chronic diseases, such as hypertension, type 2 diabetes (T2DM), stroke, coronary artery disease (CAD), cancer, and chronic lung disease [4].