Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy

作者：Yunnan Lu, Xiaohua Zhu, Y. Xu, Yongxin Li, Qingyong Dai, Xia Chang · 发表于：Frontiers in Aging Neuroscience · 年份：2025 · DOI：10.3389/fnagi.2025.1587861 · 被引用次数：10 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Acute Ischemic Stroke Management、Venous Thromboembolism Diagnosis and Management

Background The imbalance in the nutrition-immunity-inflammation status is linked to the prognosis of various diseases. This study sought to evaluate the correlation between the C-reactive protein-albumin-lymphocyte (CALLY) index and the outcomes of acute ischemic stroke (AIS) managed with endovascular thrombectomy (EVT). Methods This study retrospectively enrolled 473 AIS patients who underwent EVT from a multicenter investigation. Poor functional outcome was defined as a modified Rankin scale score exceeding 2 points at 90 days after EVT. The cutoff value for the CALLY index was determined using the receiver operating characteristic curve. Multivariable logistic regression models were utilized to explore the association between the CALLY index and poor functional outcome and restricted cubic splines was used to illustrate the relationship between the CALLY index and the risk of poor functional outcome after EVT. Results Poor functional outcomes occurred in 214 (45.2%) patients at 90 days after EVT. The cutoff for the CALLY index was 10^ (−0.635). Multivariate logistic regression revealed that the CALLY index was significantly associated with poor functional outcome (odds ratio [OR]: 0.80, 95% confidence interval [CI]: 0.70–0.91, p < 0.001; high versus low OR: 0.64, 95% CI: 0.41–1.00, p = 0.048). The restricted cubic spline analysis indicated an inverse association between the CALLY index and the risk of poor functional outcome ( P for nonlinearity = 0.373). Conclusion...