The Associations Between Gallstone Disease and Pan‐Cancer Incidence Risk Based on Over 13 Million Participants

作者：Wenqian Yu, Jin Zhou, Jing Luo, Jing Xia, Shiyi Li, Linjun Xie, Yazhou He, Hongyu Li, Guoheng Jiang, Xin Chen, Xuan Bai, Min Mao, Xin Wang · 发表于：Cancer Medicine · 年份：2025 · DOI：10.1002/cam4.70857 · 被引用次数：4 · 研究领域：Gallbladder and Bile Duct Disorders、Cholangiocarcinoma and Gallbladder Cancer Studies、Biliary and Gastrointestinal Fistulas

BACKGROUND: Increasing evidence connects gallstone disease (GSD) to all types of cancer incidence; however, the results were inconsistent. The present study aimed to evaluate whether and to what extent these associations exist comprehensively. METHODS: We systematically searched published longitudinal studies indexed in PubMed and Embase database from dates of inception to March 31, 2020. We pooled the effect of GSD on all-cause cancer incidence. Moreover, we further employed stratified analysis concerning sex, geographic background, surgery status, and follow-up period. Trial sequential analysis (TSA) was applied to decide whether the included sample size was sufficient for evaluating these associations. RESULTS: Fifty-one studies incorporating over 13 million participants were eligible for analysis in this study. GSD pose an increased risk of all-cause cancer risk (pooled RR = 1.43; 95% CI: 1.33-1.54) compared with the healthy controls, especially hematologic malignancy (pooled RR = 1.14; 95% CI: 1.05-1.25), gastrointestinal cancers (pooled RR = 1.28; 95% CI: 1.15-1.41), liver, pancreas, and biliary tract cancer (pooled RR = 1.84; 95% CI: 1.62-2.10), and kidney cancer (pooled RR = 1.19; 95% CI: 1.03-1.37). These associations are not markedly changed after stratification by different subgroups. Moreover, the TSA confirmed the sample size was sufficient to draw these conclusive conclusions. CONCLUSIONS: The present meta-analysis with sufficient evidence indicates GSD increase...