Association between stress hyperglycemia ratio (SHR) and long-term mortality in patients with ischemic stroke: a retrospective cohort study

作者：Man Huang, Wan Wang, Dong‐Mei Ren, Yanqing Chen, Ying Li, Yan Li, Wu‐lin Li, Fei Wang · 发表于：Cardiovascular Diabetology · 年份：2025 · DOI：10.1186/s12933-025-02730-8 · 被引用次数：11 · 研究领域：Hyperglycemia and glycemic control in critically ill and hospitalized patients、Neurological and metabolic disorders、Acute Ischemic Stroke Management

BACKGROUND: The stress hyperglycemia ratio (SHR) at the time of admission has been linked to short-term adverse outcomes in patients suffering from ischemic stroke (IS). However, the connection between SHR and long-term mortality in cases of IS has yet to be investigated. This study aimed to elucidate the connection between SHR and long-term mortality in IS patients, while also investigating the impact of stratification status on this relationship. METHODS: Data regarding IS patients were extracted from our medical institution's undisclosed internal stroke database, spanning from January 2016 to December 2023. Participants were classified into three groups according to the tertiles of continuous SHR. The primary outcome centered on all-cause mortality over a six-year period, whereas the secondary outcome focused on in-hospital all-cause mortality. Cox regression analysis and Kaplan-Meier curves were utilized to assess the connection between SHR and mortality rates. To further investigate the nature of this relationship, a restricted cubic spline (RCS) analysis was performed to determine its linearity, and an iterative algorithm was employed to pinpoint the inflection points. Variations among the strata were depicted in a subgroup forest plot. The prognostic ability of SHR concerning mortality risk was illustrated through receiver operating characteristic (ROC) curves. RESULTS: Among the 4330 participants, the mean age was 69.3 ± 13.4 years, with 2805 individuals (64.8%) ident...