dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction

作者：Pak‐Hin Hinson Cheung, Hua Yang, Li Wu · 发表于：Journal of Virology · 年份：2025 · DOI：10.1128/jvi.00302-25 · 被引用次数：6 · 研究领域：interferon and immune responses、HIV Research and Treatment、Immunotherapy and Immune Responses

SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its dNTPase activity. Instead, the versatility of SAMHD1-mediated restriction of various viruses suggests that its antiviral mechanisms extend beyond dNTP depletion. This explains the multifaceted and broad restriction functions of SAMHD1 that play a significant role in innate antiviral immunity.