Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study

作者：Marian Rewers, Daniel Agardh, Suzanne Bennett Johnson, Ezio Bonifacio, Helena Elding Larsson, Patricia Gesualdo, William Hagopian, Michael J. Haller, Heikki Hyöty, Randi K. Johnson, Richard McIndoe, Eoin McKinney, Jessica Melin, Åke Lernmark, Richard E. Lloyd, Kristian Lynch, Jill M. Norris, Stephen S. Rich, Roswith Roth, Desmond Schatz, Jorma Toppari, Eric W. Triplett, Kendra Vehik, Suvi Μ. Virtanen, Anette‐Gabriele Ziegler, Beena Akolkar, Jeffrey P. Krischer, TEDDY Study Group, Marian Rewers, Kimberly Bautista, Judith Baxter, Daniel Felipe-Morales, Brigitte I. Frohnert, Marisa Stahl, Patricia Gesualdo, Michelle Hoffman, Randi K. Johnson, Rachel Karban, Edwin Liu, Jill Norris, Holly O’Donnell, Andrea K. Steck, Kathleen Waugh, Jorma Toppari, Olli Simell, Annika Adamsson, Suvi Ahonen, Iris Erlund, Sirpa Anttila, Leena Hakola, Sanni Heikura, Heikki Hyöty, Jorma Ilonen, Saori Itoshima, Sanna Jokipuu, Taru Karjalainen, Leena Eklund Karlsson, Pieta Kemppainen, Jukka Kero, Marika Korpela, Jaakko J. Koskenniemi, Miia Kähönen, Mikael Knip, Minna-Liisa Koivikko, Katja Kokkonen, Merja Koskinen, Mirva Koreasalo, Kalle Kurppa, Salla Kuusela, Jarita Kytölä, Jutta E. Laiho, Tiina Latva-aho, Siiri Leisku, Laura Leppänen, Katri Lindfors, Maria Lönnrot, Elina Mäntymäki, Markus Mattila, Maija E. Miettinen, Teija Mykkänen, Tiina Niininen, Sari Niinistö, Noora Nurminen, Sami Oikarinen, Hanna-Leena Oinas, Paula Ollikainen, Zhian Othmani, Sirpa Pohjola, Jenna Rautanen, M. F. Rein, Minna Romo, Juulia Rönkä, Nelli Rönkä, Noora Ruotsalainen, Satu Simell, Päivi Tossavainen, Mari Vähä-Mäkilä, Eeva Varjonen, Riitta Veijola, Irene Viinikangas, Suvi Μ. Virtanen, Richard McIndoe, Desmond Schatz, Diane Hopkins, Michael Haller, Melissa Gardiner, Ashok Sharma, Laura M. Jacobsen, Percy Gordon, Jennifer Hosford, Anette-G. Ziegler, Ezio Bonifacio, Cigdem Sanverdi, Anja Heublein, Sandra Hummel, Annette Knopff, Melanie Köger, Sibylle Koletzko, Claudia Ramminger, Roswith Roth, Jennifer Schmidt, Marlon Scholz, Joanna Stock, Katharina Warncke, Lorena Müller, Christiane Winkler, Åke Lernmark, Daniel Agardh, Carin Andrén Aronsson, Rasmus Bennet, Corrado Cilio, Susanne Dahlberg, Malin Goldman Tsubarah, Emelie Ericson-Hallström, Lina Fransson, Emina Halilovic, Susanne Hyberg, Berglind Jónsdóttir, Naghmeh Karimi, Helena Elding Larsson, Markus Lundgren, Jessica Melin, Kobra Rahmati, Anita Ramelius, Falastin Salami, Anette Sjöberg, Evelyn Tekum Amboh, Carina Törn, Terese Wiktorsson, Eva Andersson, Marie Andersson Turpeinen, Rawya Antar, Maria Ask, Jenny Bremer, Sylvia Bianconi Svensson, Ulla-Marie Carlsson, Magdalena Delikat Kulinski, Annika Fors, Ulla Fält, Thomas Gard, Joanna Gerardsson, Monika Hansen, Anna Hansson, Carina Hansson, Gertie Hansson, Elin M Hård Af Segerstad, Hanna Jisser, Fredrik Johansen, Linda Jönsson, Silvija Jović, Sigrid Lenrick Forss, Barbro Lernmark, Marielle Lindström, Maria Markan, Theodosia Massadakis, Marlena Maziarz, Zeliha Mestan, Maria Månsson Martinez, Caroline Nilsson, Emma Nilsson, Yohanna Nordh, Karin Ottosson, Sara Rang, Anna Rosenquist, Monika Sedig Järvirova, Sara Sibthorpe, Birgitta Janerot-Sjöberg, Ulrika Swartling, Erika Trulsson, Ulrika Ulvenhag, Anne Wallin, Ingrid Wigheden, Åsa Wimar, Sofie Åberg, William Hagopian, Michael Killian, Claire Cowen Crouch, Jennifer Skidmore, Ben Kim, Cody McCall, Arlene Meyer, Jared Radtke, Shreya Roy, Dorothy Becker, Margaret Franciscus, MaryEllen Dalmagro-Elias Smith, Ashi Daftary, Mary Beth Klein, Chrystal Yates, Jeffrey P. Krischer, Rajesh Adusumali, Sarah Austin-Gonzalez, Maryouri Avendano, Sandra Baethke, Brant Burkhardt, Martha Butterworth, Nicholas Cadigan, Joanna Clasen, Kevin Counts, Laura Gandolfo, Jennifer Garmeson, Veena Gowda, Shu Liu, Xiang Liu, Kristian Lynch, Jamie Malloy, Lazarus Mramba, Cristina McCarthy, Hemang Parikh, Cassandra Remedios, Chris Shaffer, Susan Smith, Noah Sulman, Roy Tamura, Dena Tewey, Henri Thuma, Michael J. Toth, Ulla Uusitalo, Kendra Vehik, Ponni Vijayakandipan, Melissa Wroble, Jimin Yang, Kenneth C. Young, Michael Abbondondolo, Lori Ballard, Rasheedah Brown, David Cuthbertson, Stephen Dankyi, Christopher Eberhard, Steven Fiske, David Hadley, Kathleen Heyman, Belinda Hsiao, Christina Karges, Francisco Perez Laras, Hye Seung Lee, Qian Li, Colleen Maguire, Wendy McLeod, Aubrie Merrell, Steven Meulemans, José L. Moreno, Ryan Quigley, Laura Smith, Liping Yu, Dongmei Miao, Kathleen M. Gillespie, Kyla Chandler, Olivia Pearce, Sarah Stollery, Elinor Balch, Hanah Batholomew, Zahra Hashmi, Elisabeth Aardal Eriksson, Ing-Marie Lundgren, E Karlsson, Dzeneta Neszirevic Dernroth, Michael Kalnoski, Chao-Nan Ting, Iris Erlund, Terhi Vihervaara, Petra Arohonka, Inga Liukko, Linda Patrikainen, Outi Ruotsalainen, Tiina Keippila, Stephen S. Rich, Wei‐Min Chen, Suna Önengüt-Gümüşcü, Emily Farber, Rebecca Roche Pickin, Jonathan M. Davis, Jordan P. Davis, Dan Gallo, Jessica Bonnie, Paul Campolieto, Randie R. Little, Kuanysh Kabytaev, Curt L. Rohlfing, William Hagopian, Jared Radtke, Henry Erlich, Steven J. Mack, Anna Lisa Fear, Oliver Fiehn, Bill Wikoff, Brian C. DeFelice, Dmitry Grapov, Tobias Kind, Mine Palazoglu, Luis Valdiviez, Benjamin Wancewicz, Gert Wohlgemuth, Joyce Wong, Joseph F. Petrosino, Richard E. Lloyd, Nadim J. Ajami, Tulin Ayvaz, Tonya Bauch, HarshaVardhan Doddapaneni, Richard A. Gibbs, Rachel Hirsch, Kristi L. Hoffman, Hanna Houston, Diane S. Hutchinson, Sara Javornik Cregeen, E Laval, Lenka Kusic, Ginger Metcalf, Hannah Moreno, Donna M. Muzny, Jacqueline O’Brien, Katelyn Payne, Ashlie Renner, Lauren Riley, Matthew C. Ross, Daniel P. Smith, Anil Surathu, Auriole Tamegnon, Xiangjun Tian, Michael J. Tisza, Nguyen Truong, Li Wang, Matthew C. Wong, E Zavala, Clive Wasserfall, William E. Winter, David L. Pittman, Santica M. Marcovina, Andrew N. Hoofnagle, Thomas Metz, Bobbie‐Jo Webb‐Robertson, Ernesto Nakayasu, Lisa Bramer, Athena Schepmoes, Panshak Dakup, Jin‐Xiong She, Richard McIndoe, Haitao Liu, John Nechtman, Yansheng Zhao, Na Jiang, Yanna Tian, Guangkuo Dong, Clive Wasserfall, William E. Winter, David L. Pittman, Chris Deigan, Ricky Schrock, Polina Malone, Sandra Ke, Niveen Mulholland, Beena Akolkar, Thomas Briese, Todd M. Brusko, Teresa Buckner, Suzanne Bennett Johnson, Eoin McKinney, Tomi Pastinen, Steffen Ullitz Thorsen, Eric W. Triplett · 发表于：Diabetes Care · 年份：2025 · DOI：10.2337/dc24-2886 · 被引用次数：11 · 研究领域：Diabetes and associated disorders

In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic diseases, including diabetes and other endocrine, metabolic, and digestive disorders, by funding innovative research to develop better treatment and prevention and a cure for these conditions. Autoimmunity that leads to type 1 diabetes or celiac disease or thyroid autoimmunity affects 1 in 20 children and adolescents in the U.S. While treatments are available, prevention of these common autoimmune diseases has been elusive due to poor understanding of the environmental causes and their interactions with common predisposing or protective genetic variants. In 2002, the NIDDK established The Environmental Determinants of Diabetes in the Young (TEDDY) consortium to advance understanding of the causes and the natural history of type 1 diabetes and other autoimmune diseases. The overarching goal of TEDDY is to inform novel approaches to primary prevention of autoimmunity. In this large international prospective birth cohort study, standardized information has been collected concerning candidate environmental exposures along with serial blood, stool, nasal swab, and other biosamples, with creation of a central repository of data and biologic samples for hypothesis-based research. This review summarizes TEDDY's major contributions to...