Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration

作者：Qiankun Yang, Xiaoyu Zhu, Li Zhang, Fei Luo · 发表于：Cardiovascular Diabetology · 年份：2025 · DOI：10.1186/s12933-025-02695-8 · 被引用次数：20 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、HIV-related health complications and treatments、Genetics, Aging, and Longevity in Model Organisms

BACKGROUND: Dyslipidemia has been proved to play a pivotal role in biological aging. Atherogenic Index of Plasma (AIP), derived from serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), is an effective biomarker of dyslipidemia. However, whether AIP can be used as an indicator of biological aging remains unclear. This study aims to investigate the relationship between AIP and biological aging in the US adult population. METHODS: 4,471 American adults with age over 20 years from the National Health and Nutrition Examination Survey (NHANES) database were included in this study. Biological aging was assessed by phenotypic age acceleration (PhenoAgeAccel). Multivariable linear regression models, subgroup analyses and interaction tests were employed to explore the association between AIP and PhenoAgeAccel. Furthermore, adjusted restricted cubic spline (RCS) analyses were employed to assess potential nonlinear relationships, while mediation analysis was utilized to identify the mediating effects of homeostatic model assessment of insulin resistance (HOMA-IR). Besides, network pharmacology was performed to determine the potential mechanisms underlying dyslipidemia-related aging acceleration. RESULTS: A total of 4,471 participants were included in this study, the median chronological age, PhenoAge and PhenoAgeAccel for the overall population were 49 (35-64) years, 42.85 (27.30-59.68) years, and - 6.92 (- 10.52 to -2.46) years, respectively. In the fully adjusted ...