Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution

作者：Kami Pekayvaz, Badr Kilani, Markus Joppich, Luke Eivers, Sophia Brambs, Viktoria Knottenberg, Sezer Akgöl, Keyang Yue, L LI, Alejandro Martinez-Navarro, Rainer Kaiser, Nina Meißner, Heiko Schulz, Larissa Belz, Anastassia Akhalkatsi, Sven Stockhausen, Tonina T. Mueller, Simon Millonig, Lea Hartelt, Christoph Gold, Aleksandar Janjic, Vivien Polewka, Franziska Wendler, Augustin Droste zu Senden, Anna Titova, Alexander Leunig, Michael Voelkl, Bernd Engelmann, Moritz Roman Hernández Petzsche, Tobias Boeckh‐Behrens, Thomas Liebig, Sandra Winning, Joachim Fandrey, Martin Dichgans, Wolfgang Enard, Ralf Zimmer, Steffen Tiedt, Steffen Maßberg, Leo Nicolai, Konstantin Stark · 发表于：Immunity · 年份：2025 · DOI：10.1016/j.immuni.2025.03.020 · 被引用次数：28 · 研究领域：Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Atherosclerosis and Cardiovascular Diseases、Cell Adhesion Molecules Research

phenotype. This immunothrombolytic axis results in thrombus resolution. Together, with this immune landscape of thrombosis, we provide a valuable resource and introduce the concept of "immunothrombolysis" with broad mechanistic and translational implications at the crossroad of inflammation and thrombosis.