Standard breath-hold versus free-breathing real-time cine cardiac MRI—a prospective randomized comparison in patients with known or suspected cardiac disease

作者：Mohamed Elshibly, Simran Shergill, Kelly Parke, Charley Budgeon, Rachel England, Ciaran Grafton‐Clarke, Fathelrahman Elshibly, Peter Kellman, Gerry P McCann, Jayanth R. Arnold · 发表于：European Heart Journal - Imaging Methods and Practice · 年份：2025 · DOI：10.1093/ehjimp/qyaf042 · 被引用次数：8 · 研究领域：Cardiac Imaging and Diagnostics、Advanced MRI Techniques and Applications、Cardiovascular Function and Risk Factors

Aims: Cardiovascular magnetic resonance (CMR) is established as the reference standard for cardiac volumetric assessment. Despite the accuracy and robustness of steady-state free precession (SSFP) cine imaging, its use may prove challenging in patients with arrhythmia and in those who cannot perform repeated breath holds. An alternative solution may be a free-breathing electrocardiogram (ECG)-triggered, retro-gated, real-time cine sequence. This study sought to compare left ventricular volumetric, wall motion, and thickness assessment with both techniques. Methods and results: Consecutive patients with known or suspected cardiac disease referred for clinical CMR were studied at 3-Tesla. Participants underwent short-axis standard SSFP and real-time cine imaging in a randomized order within the same scan. Between sequence agreement and mean difference were compared for end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume, ejection fraction (EF), left ventricular mass (LVM), maximal wall thickness (MWT), and wall motion score index (WMSi). Two hundred and two patients (mean age 61 ± 14 years, 51% male and 14% irregular rhythm) were studied. All left ventricular indices showed good-excellent agreement between the two methods [intraclass correlation coefficient (95% confidence interval), EDV 0.96 (0.95-0.97), ESV 0.96 (0.94-0.97), EF 0.85 (0.81-0.88), LVM 0.93 (0.91-0.95), MWT 0.80 (0.75-0.85), and WMSi 0.93 (0.91-0.95)]. Conclusion: In patients with known or suspe...