White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease

作者：Mariyemuguli Reheman, Sagar Buch, Naying He, Pei Huang, Qiurong Yu, Xinhui Wang, Yu Liu, Youmin Zhang, Zhijia Jin, Yan Li, Peng Liu, Shengdi Chen, E. Mark Haacke, Fuhua Yan · 发表于：NeuroImage · 年份：2025 · DOI：10.1016/j.neuroimage.2025.121236 · 被引用次数：5 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Neurological disorders and treatments、Dementia and Cognitive Impairment Research

• Patients with Parkinson's disease (PD) and cognitive impairment demonstrated a significantly greater burden of white matter hyperintensities (WMH), with the highest burden observed in those with PD dementia. Moreover, total WMH volume showed a significant negative correlation with cognitive scores. • Quantitative MRI (qMRI) measures of tissue properties, including water content, T1, and T2*, were significantly elevated in WMH lesions compared to normal-appearing white matter (NAWM). Additionally, qMRI effectively captured the heterogeneity of tissue properties within WMH. • Water content, T1, and T2* exhibited a gradient of decreasing intensity from the ventricles toward the periphery, as demonstrated by tissue property heatmaps and lesion-ventricle distance profiles. • Voxel-wise analysis revealed a significant negative correlation between the qMRI tissue properties of periventricular WMH and MoCA scores. The pathological relationship between white matter hyperintensities (WMH) and cognitive impairment in Parkinson's disease (PD) remains unclear due to their variable locations, heterogeneity, and limited assessment of underlying tissue properties. This study integrates T2-FLAIR and quantitative MRI (qMRI) to investigate burden, spatial distribution, and extent of tissue alterations in WMH, aiming to elucidate their role in cognitive decline among PD patients. A total of 122 age- and sex-matched PD patients and 65 healthy controls (HC) were recruited, with PD patients group...