Mitochondrial transfer drives immune evasion in tumor microenvironment

作者：Qiang Cai, Xiaojun Cai, Quazi T.H. Shubhra · 发表于：Trends in cancer · 年份：2025 · DOI：10.1016/j.trecan.2025.04.002 · 被引用次数：12 · 研究领域：Immune cells in cancer、Cancer, Hypoxia, and Metabolism、Ferroptosis and cancer prognosis

Tumors subvert T cell metabolism through diverse mechanisms. Ikeda et al. reveal mitochondrial transfer as a tumor-driven immune evasion strategy, where cancer cells deliver dysfunctional mitochondria to T cells, impairing metabolism and inducing exhaustion. These findings highlight mitochondrial dynamics as a promising therapeutic target to improve immunotherapy outcomes.