Subjective and Objective Cancer‐Related Cognitive Impairments Among Systemic and Radiation Therapy‐Naïve Female Cancer Patients

作者：Maria‐Chidi Christiana Onyedibe, Martina E. Schmidt, Pauline Bizer, Philipp Zimmer, Karen Steindorf · 发表于：Cancer Medicine · 年份：2025 · DOI：10.1002/cam4.70908 · 被引用次数：12 · 研究领域：Cancer-related cognitive impairment studies、Cancer survivorship and care、Brain Metastases and Treatment

BACKGROUND: Cancer-related cognitive impairment (CRCI) is a frequent and burdensome problem that is still insufficiently understood and managed. We investigated subjective and objective measures of CRCI, as recommended by the International Cancer and Cognition Task Force (ICCTF) in cancer patients prior to systemic or radiation therapy with respect to potential influencing or associated psychosocial, demographic, or lifestyle factors. METHODS: Female patients with breast or gynecological tumors (n = 239, mean age = 55.5, SD = 11.6) prior to any systemic or radiation therapy completed validated subjective (FACT-Cog: perceived cognitive impairment [PCI], perceived cognitive ability [PCA], impact on quality of life [IQoL]) and objective measures of CRCI (Trail Making Test [TMT-A and -B], Controlled Oral Word Association Test [COWA], and Hopkins Verbal Learning Test-Revised [HVLT-R]). Association with cross-sectionally assessed age, body mass index, education, smoking, alcohol intake, sleep problems, social support, anxiety, and pain was investigated using multiple linear regression models. RESULTS: A quarter (25.1%) of patients showed indication for CRCI based on the PCI score. Subjective and objective CRCI measures showed no or only weak correlations, also when adjusting for age and education (partial Spearman correlations with each other, all |r| ≤ 0.21). Anxiety, sleep problems, and pain were significantly associated with low subjective cognitive function (PCI, PCA, and IQoL)...