Indications and contraindications to platelet‐rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: A 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections)

作者：Florent Eymard, Karine Louati, É. Noël, Rédouane Abouqal, P. Adam, Fadoua Allali, Gabriel Antherieu, Jo Caers, Fabrice Cognasse, Hervé Collado, Christelle Darrieutort‐Laffite, Corinne Frère, Alain Frey, Mathilde Gavillet, Vincent Grémeaux, Maël Heiblig, Guy Jérusalem, Charlotte Joly, Jean‐François Kaux, Martin Lamontagne, Mathieu Leclerc, Philippe Léonard, R. Lepeule, Daniel Lopez‐Trabada‐Ataz, Jérémy Magalon, Fabrice Michel, Paul Ornetti, Cécile Oury, Elvire Pons‐Tostivint, Fernando Real, Ghislaine Robert, Mikel Sánchez, Alain Silvestre, Hervé Bard · 发表于：Knee Surgery Sports Traumatology Arthroscopy · 年份：2025 · DOI：10.1002/ksa.12682 · 被引用次数：12 · 研究领域：Periodontal Regeneration and Treatments、Orthopaedic implants and arthroplasty、Musculoskeletal synovial abnormalities and treatments

PURPOSE: Platelet-rich plasma (PRP) could be a vector for certain diseases, and its composition may vary by pathologic condition. The main comorbidities that could affect PRP composition are infectious, oncologic and haematologic. In addition to potential alteration of clinical response, these pathologies could have a significant impact on the local tolerance of PRP as well as a risk of disease dissemination to the injection site. To date, there are few specific recommendations related to these comorbidities to guide clinicians. Therefore, the International Research Group on Platelet Injections (GRIIP) supported a consensus project to develop these recommendations. METHODS: Following the 'recommendations by formal consensus' methodology, a steering committee performed a literature review and drafted an initial set of recommendations. They were evaluated by an international rating group (15 specialists in musculoskeletal [MSK] diseases, five haematologists, four oncologists, three infectiologists and four scientists specialising in platelet physiology). From this rating, the first set of recommendations was discussed in a plenary meeting and then modified by the steering committee. Finally, four overarching principles and 23 recommendations were re-evaluated by the rating group. Recommendations were classified as appropriate or not, with strong or relative agreement, or uncertain. RESULTS: From the 23 recommendations, 10 concerned infectious diseases (viral and bacterial infec...