Role of impulse oscillometry in chronic obstructive pulmonary disease and asthma‐chronic obstructive pulmonary disease overlap

作者：Yuning Huang, Xue Zhang, J. Wang, Wuping Bao, Chengjian Lv, Yingying Zhang, Xue Tian, Yan Zhou, Min Zhang · 发表于：Clinical and Translational Allergy · 年份：2025 · DOI：10.1002/clt2.70057 · 被引用次数：5 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Asthma and respiratory diseases、Inhalation and Respiratory Drug Delivery

Abstract Background Small airway dysfunction (SAD) is critical in chronic obstructive pulmonary disease (COPD) and asthma‐COPD overlap (ACO), impacting disease severity, acute exacerbation (AE) risk, and prognosis. Traditional spirometry may miss SAD due to its reliance on forced vital capacity. Objective This study investigates the role of impulse oscillometry system (IOS) for early detection, disease monitoring, and AE prediction. Methods Pathological specimens from 64 patients with normal lung function were divided into small airway pathological abnormalities (PAs, n = 38) and normal pathology (PN, n = 26). Logistic regression and receiver operating characteristic (ROC) curve analysis evaluated IOS's predictive value for SAD. Additionally, 37 healthy volunteers, 125 COPD patients, and 128 ACO patients underwent spirometry, IOS, FeNO, CT scans, and blood tests. Correlations between IOS and spirometry indices were evaluated. One‐year follow‐up of 140 patients assessed IOS's predictive capability for AE. Results ROC analysis indicated that R5 − R20 combined with FEF 75 %pred best predicted PAs (areas under the ROC curves [AUC] = 0.80). R5 − R20, with a cut‐off of 0.09 kPa/[L/s], demonstrated 85.6% sensitivity and 72.9% specificity in distinguishing COPD from healthy individuals, and 89.1% sensitivity with 72.9% specificity for ACO. In COPD, R5 − R20 correlated strongly with spirometry indices ( r = 0.60), while Fres correlated well in ACO ( r = 0.48) for FEV 1 %pred ≥ 50%, wi...