Bioactive Sesterterpenoids from the Mangrove-Derived Aspergillus sp. GXIMD 03023

作者：Jiali He, Yu Wang, Xiangxi Yi, Yuman Gan, Yonghong Liu, Chenghai Gao, Kai Liu, Meng Bai · 发表于：Journal of Natural Products · 年份：2025 · DOI：10.1021/acs.jnatprod.5c00182 · 被引用次数：4 · 研究领域：Microbial Natural Products and Biosynthesis、Marine Sponges and Natural Products、Phytochemical compounds biological activities

Four novel sesterterpenoids, asperterpenoids Q–T ( 1 – 4 ), featuring a rare 5/7/(3)6/5 pentacyclic skeleton were isolated from the mangrove-derived fungus Aspergillus sp. GXIMD 03023 using an NMR-guided approach. Their structures and absolute configurations were determined by comprehensive spectroscopic analysis, including 1D/2D-NMR and HRESIMS, supplemented by experimental and ECD spectral matching, DFT-calculated 13 C NMR chemical shifts, and DP4plus probability analysis. Compounds 1 – 4 were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. Compound 1 showed weak activity against Vibrio harveyi and Xanthomonas campestris, with MIC values of 3.12 and 6.25 μg/mL, respectively. Compound 3 had significant inhibitory activity against BPH with an IC 50 value of 3.68 μM.