Vitamin D for primary dysmenorrhea and endometriosis-related pain – A systematic review of registered RCTs

作者：Iris Wenyu Zhou, Anthony Lin Zhang, Miranda Sin‐Man Tsang, Charlie Changli Xue · 发表于：PLoS ONE · 年份：2025 · DOI：10.1371/journal.pone.0321393 · 被引用次数：7 · 研究领域：Vitamin D Research Studies、Menstrual Health and Disorders、Endometriosis Research and Treatment

OBJECTIVE: This systematic review investigates the potential role of vitamin D supplement in alleviating pain associated with primary dysmenorrhea or endometriosis by analysing registered randomised controlled trials (RCTs). METHODS: We comprehensively searched the WHO International Clinical Trials Registry Platform to identify registered RCTs that assessed the effects of vitamin D supplement on pain outcomes in people with primary dysmenorrhea or endometriosis. The primary outcomes of interest were pain severity/intensity, pain duration, pain medication usage and pain-related outcome measurements. RESULTS: Seven registered RCTs were included in this systematic review. These RCTs had diverse doses and treatment durations of vitamin D supplement used as intervention. They also had either high or some concerns of risk of bias, according to Cochrane risk of bias version 2 assessment. Substantial heterogeneities were generally observed across the seven RCTs. When measured using a validated tool visual analogue scale (VAS), pain severity was significantly lower at the end of treatment when compared with placebo (mean difference MD -1.12, 95% confidence interval [-2.16, -0.07], I2=81%, 5 studies, n = 308). This significant difference was observed in the primary dysmenorrhea RCTs, but not the endometriosis RCTs. CONCLUSION: This systematic review identified vitamin D may reduce pain associated with primary dysmenorrhea, though a low certainty of evidence was available. Future studie...