Functional outcomes in pediatric patients on renal replacement therapy in a worldwide registry

作者：Kristin Dolan, Katja M. Gist, Abby Basalely, Gabriella Bottari, Abhishek Chakraborty, Mihaela Damian, Dana Y. Fuhrman, Denise Hasson, Catherine Joseph, David M. Kwiatkowski, Susan D. Martin, Jenn Nhan, Nicholas J. Ollberding, David T. Selewski, Danielle E. Soranno, Michelle C. Starr, Amy E. Strong, Sameer Thadani, Huaiyu Zang, Ayse Akcan‐Arikan, the WE-ROCK Collaborative, Emily Ahern, Ayse Akcan‐Arikan, Issa Alhamoud, Rashid Alobaidi, Pilar Antón-Martín, Shanthi S. Balani, Matthew Barhight, Abby Basalely, Amee M. Bigelow, Gabriella Bottari, Andrea Cappoli, Eileen Ciccia, Michaela Collins, Denise Colosimo, Gérard Cortina, Mihaela Damian, Sara de la Mata Navazo, Gabrielle DeAbreu, Akash Deep, Kathy L Ding, Kristin J Dolan, Sarah N. Fernández, Dana Y. Fuhrman, Ben Gelbart, Katja M Gist, Stephen M. Gorga, Francesco Guzzi, Isabella Guzzo, Taiki Haga, Elizabeth Harvey, Denise Hasson, Taylor Hill-Horowitz, Haleigh Inthavong, Catherine Joseph, Ahmad Kaddourah, Aadil Kakajiwala, Aaron Kessel, S Korn, Kelli A. Krallman, David M. Kwiatkowski, Jasmine Lee, Laurance Lequier, Tina Madani Kia, Kenneth E. Mah, Eleonora Marinari, Susan D. Martin, Shina Menon, Tahagod Mohamed, Catherine Morgan, Theresa Mottes, Melissa Muff‐Luett, Siva P. Namachivayam, Tara M. Neumayr, Jennifer Nhan, Abigail Alexandra O'Rourke, Nicholas J. Ollberding, Matthew G. Pinto, Dua Qutob, Valeria Raggi, Stéphanie Reynaud, Zaccaria Ricci, Zachary A. Rumlow, María José Santiago, Emily See, David T Selewski, Carmela Serpe, Alyssa Serratore, Ananya Shah, Weiwen V. Shih, Hyungoo Shin, Cara Slagle, Sonia Solomon, Danielle E. Soranno, Rachana Srivastava, Natalja L. Stanski, Michelle C. Starr, Erin K. Stenson, Amy E. Strong, Susan A. Taylor, Sameer Thadani, Amanda M. Uber, Brynna Van Wyk, Tennille N. Webb, Huaiyu Zang, Emily E. Zangla, Michael Zappitelli · 发表于：Nephrology Dialysis Transplantation · 年份：2025 · DOI：10.1093/ndt/gfaf067 · 被引用次数：4 · 研究领域：Acute Kidney Injury Research、Dialysis and Renal Disease Management、Trauma, Hemostasis, Coagulopathy, Resuscitation

BACKGROUND AND HYPOTHESIS: Mortality rates of children supported with continuous renal replacement therapy (CRRT) have improved, yet morbidity remains high. We aimed to evaluate the functional outcomes of children receiving CRRT using Functional Status Scale (FSS). We hypothesized that children receiving CRRT will have worse FSS compared with their baseline and acquire new morbidity at hospital discharge and 6 and 12 months post-discharge, and that lack of renal recovery will contribute to worsening functional status. METHODS: This is a retrospective chart review from The Worldwide Exploration of Renal Replacement Outcomes Collaborate in Kidney Disease (WE-ROCK), an international multi-center registry. Twenty-eight centers across five countries participated in this analysis. Children from birth to 25 years, on CRRT for acute kidney injury (AKI) or fluid overload, were included. Patients with underlying kidney disease, on extracorporeal membrane oxygenation and non-survivors were excluded. FSS was collected at discharge (n = 527), 6 months (n = 387) and 12 months post-discharge (n = 344). The primary outcome was FSS at discharge and 6 months. Secondary outcomes included: new morbidity at discharge and 6 months; FSS at 12 months; and the impact of renal recovery on functional outcomes. RESULTS: A total of 527 patients had median FSS of 7 (6, 90) at hospital discharge. Thirty-nine percent (n = 204) had worse FSS. Eighteen percent (95/527) acquired a new morbidity at discharge. P...