Foundation model-driven multimodal prognostic prediction in patients undergoing primary surgery for high-grade serous ovarian cancer

作者：Qiu Bi, Conghui Ai, Linhao Qu, Qingyue Meng, Qinqing Wang, Jing Yang, Ao Zhou, Wenwei Shi, Ying Lei, Yunzhu Wu, Yang Liu, Haiming Li, Jinwei Qiang · 发表于：npj Precision Oncology · 年份：2025 · DOI：10.1038/s41698-025-00900-1 · 被引用次数：15 · 研究领域：Radiomics and Machine Learning in Medical Imaging、Ovarian cancer diagnosis and treatment、AI in cancer detection

High-grade serous ovarian cancer (HGSOC) presents challenges in prognostic prediction. This study aimed to develop a universal foundation model-driven multimodal model (FoMu model) to assess the prognosis of HGSOC patients. We conducted a retrospective cohort study involving 712 eligible patients across four centers, collecting clinical, MRI, and hematoxylin and eosin (H&E)-stained whole slide images (WSIs) data. Pre-trained radiological and pathological foundation models were employed for feature precoding. Subsequently, we introduced unimodal and cross-modal adaptive aggregation networks to comprehensively model the features derived from each modality. Our findings revealed that both unimodal and cross-modal FoMu models exhibited superior and stable predictive capabilities for overall survival (OS) and progression-free survival (PFS). In summary, our study successfully developed a FoMu model that effectively integrates multimodal data to assess the prognoses of HGSOC patients, highlighting its potential for improving individualized patient management and clinical decision-making in future applications.