Long Non-Coding TP73-AS1: A Potential Biomarker and Therapeutic Target in Cancer

作者：Kejing Li, Dapeng Zhao, Xuena Liu, Qiyou Cao, Longzhu Ruan, Huiwen Lei, Xiaohua Chen, Xiaodong Jin, Huijuan Li, Xiaodong Xie, Cuixia Di · 发表于：International Journal of Molecular Sciences · 年份：2025 · DOI：10.3390/ijms26083886 · 被引用次数：1 · 研究领域：Cancer-related molecular mechanisms research、RNA modifications and cancer、RNA Research and Splicing

Tumor protein 73 antisense RNA 1 (TP73-AS1), a newly discovered long non-coding RNA (lncRNA), the dysregulated expression of which is closely related to the occurrence, drug resistance, and prognosis of various cancers. Exploring the regulatory mechanism of TP73-AS1 provides a new research direction for cancer diagnosis and treatment. On this basis, we briefly review the molecular structural and dual regulatory roles of TP73-AS1 in cancer. In addition, we outline its three molecular mechanisms in cancer: binding to proteins, regulating signaling pathways, and serving as molecular sponges. Subsequently, we introduce the role of TP73-AS1 in common malignant tumors such as gastric cancer (GC), lung cancer, colorectal cancer (CRC), etc. Last, emphasis is given to the potential clinical value of TP73-AS1, especially as single nucleotide polymorphisms of this lncRNA are associated with the risk of GC and CRC. Therefore, this review highlights the significance of TP73-AS1 as a novel biomarker and therapeutic target.