Digital biomarkers for real-life, home-based monitoring of frailty: a systematic review and meta-analysis

作者：Jundan Huang, Shuhan Zhou, Qi Xie, Yu Jia, Yinan Zhao, Hui Feng · 发表于：Age and Ageing · 年份：2025 · DOI：10.1093/ageing/afaf108 · 被引用次数：9 · 研究领域：Frailty in Older Adults、Chronic Disease Management Strategies、Nutrition and Health in Aging

BACKGROUND: Frailty, characterised by decreased physiological function and increased vulnerability to stressors, was associated with an increase in numerous adverse outcomes. Although the number of digital biomarkers for detecting frailty in older adults is increasing, there remains a lack of evidence regarding their effectiveness for early detection and follow-up in real-world, home-based settings. METHODS: Five databases were searched from inception until 1 August 2024. Standardised forms were utilised for data extraction. The Quality Assessment of Diagnostic Accuracy Studies was used to assess the risk of bias and applicability of included studies. A meta-analysis was conducted to assess the overall sensitivity and specificity for frailty detection. RESULTS: The systematic review included 16 studies, identifying digital biomarkers relevant for frailty detection, including gait, activity, sleep, heart rate, hand movements and room transition. Meta-analysis further revealed pooled sensitivity of 0.78 [95% confidence interval (CI): 0.70-0.86] and specificity of 0.79 (95% CI: 0.72-0.86) to classify robust and pre-frailty/frailty participants. The overall risk of bias indicated that all the included studies were characterised as having a high or unclear risk of bias. CONCLUSION: This study offers a thorough characterisation of digital biomarkers for detecting frailty, underscoring their potential for early prediction in home settings. These findings are instrumental in bridging...