Clinical Efficacy of Acupuncture Combined with Escitalopram Oxalate in the Treatment of Mild-to-Moderate Post-Stroke Depression

作者：Yang Liu, Guohui Zhang, Jingbo Li, Ying Lv, Rui Qi · 发表于：Neuropsychiatric Disease and Treatment · 年份：2025 · DOI：10.2147/ndt.s507265 · 被引用次数：7 · 研究领域：Acupuncture Treatment Research Studies、Neurological Disease Mechanisms and Treatments、Stroke Rehabilitation and Recovery

Objective: This analysis observed the clinical effect of acupuncture combined with Escitalopram oxalate in the treatment of mild to moderate post-stroke depression (PSD). Methods: This was a retrospective study of 1:1 matching design. A total of 96 cases of mild to moderate PSD patients were enrolled and divided into 48 cases each in the control group and the observation group. The control group received treatment with Escitalopram oxalate tablets. The observation group received acupuncture combined with Escitalopram Oxalate, both for a duration of 8 weeks. Comparisons were performed in regard clinical efficacy, 17-Item Hamilton Rating Scale for Depression (HAMD-17), National Institutes of Health Stroke Scale (NIHSS), Pittsburgh Sleep Quality Index (PSQI), Barthel Index, neurotransmitters (5-hydroxytryptamine [5-HT], norepinephrine [NE], and dopamine [DA]), and liver function (alanine aminotransferase [ALT], aspartate transaminase [AST], direct bilirubin [DBIL], and total bilirubin [TBIL]). The Side Effect Rating Scale (SERS) scores at weekends 4 and 8 of treatment were counted. Results: > 0.05). Conclusion: Combining acupuncture with Escitalopram oxalate proves to be effective and safe for treating mild-to-moderate PSD, significantly alleviating depression, and enhancing neurological function, sleep quality, and quality of life.