Perfluorooctanoic acid serum concentrations and half-lives in a community exposed to contaminated drinking water in New York State

作者：Elizabeth L. Lewis-Michl, Steven P. Forand, Wan‐Hsiang Hsu, Sanghamitra S. Savadatti, Ming Liu, June Moore, Qian Wu, Elizabeth J. Mullin, Kenneth M. Aldous · 发表于：Journal of Exposure Science & Environmental Epidemiology · 年份：2025 · DOI：10.1038/s41370-025-00769-z · 被引用次数：12 · 研究领域：Per- and polyfluoroalkyl substances research、Fluoride Effects and Removal、Chemical Analysis and Environmental Impact

BACKGROUND: Investigations during 2014-2016 in two communities in New York State showed perfluorooctanoic acid (PFOA) in a public system serving 3800 residents (Hoosick Falls) averaging 534 ppt and in a smaller system serving 200 residents (Petersburgh) averaging 92.5 ppt. Bottled water (2015-2016) was provided until filtration brought PFOA levels to non-detectable (2016-2017). OBJECTIVE: The New York State Department of Health (NYSDOH) sought to address community questions about exposures and evaluate reductions in serum concentrations. METHODS: NYSDOH tested serum PFOA in 2016 just after drinking water exposure mitigation and again in 2018. Descriptive statistics for serum PFOA by sex, age, length of residence, and water consumption were evaluated using multiple regression, and half-lives were estimated. RESULTS: Using the serum PFOA GM and median for tests occurring within 3 months of exposure mitigation (N = 1121) (47.5, 54.2) produced serum to water ratios of 89.0 and 101.6. A total of 1573 Hoosick Falls public water consumers (337 <age 18) participated in 2016 baseline testing. PFOA GM was 42.1 mcg/L (ppb) (CI: 39.9-44.4), 27 times higher than the U.S. population, from NHANES, 2015-2016. Concentrations were significantly higher for males, older ages, longer residence, and higher water consumption in multivariate regression. Among children, concentrations were highest among the youngest, <3 years. Half-lives for 307 participants tested in 2016 and 2018 produced a GM half...