Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer’s disease

作者：Yongkang Zhao, Wenxing Zhao, Xuejun Chai, Penghao Sun, Junlang Huang, Xinrui Guo, Lulu Zhang, Duoduo Ren, Chenju Yi, Xiaoyan Zhu, Shanting Zhao · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.04.025 · 被引用次数：14 · 研究领域：Gut microbiota and health、Alzheimer's disease research and treatments、Immune cells in cancer

• Eucommia cortex polysaccharide (EPs) alleviate learning and memory deficits in Alzheimer's disease via the gut-brain axis. • EPs ameliorate Alzheimer's disease by remodeling gut microbiota are revealed. • Expansion of short-chain fatty acid-metabolizing bacteria in the gut microbiota is associated with omprovement in Alzheimer's disease by EPs. • Short-chain fatty acids metabolized by gut microbiota modulate glutamine synthase activity as an important mediator of EPs ameliorating Alzheimer's disease. • EPs can alleviate the brain microenvironment in Alzheimer's diaease and inhibit β-amyloid formation and deposition via the gut-brain axis. Alzheimer’s disease (AD), which is a chronic neurodegenerative disorder, is marked by the progressive deteriorations in learning and memory capabilities. The microbiota-gut-brain axis has come to be regarded as a crucial element in relation to the pathogenesis as well as the treatment of AD. Eucommiae cortex polysaccharides (EPs), being among the most plentiful substances present in the Eucommiae cortex, show the potential to exert immunomodulatory and neuroprotective function. However, whether EPs are protective against AD and their mechanism of action remain to be investigated We hypothesize that EPs can regulate brain glutamine metabolism through gut microbiota and the butyric acid metabolized by them, improve oxidative stress and autophagy in the brain, and thus alleviate AD. In the present study, we used EPs (0.25 % w/w in food) and f...