Enantioselective and Regiodivergent Skeletal Transformations of 1,2,3-Thiadiazoles to Alkylidene Dihydrothiophenes

作者：Cunzhi Chen, You-Wei Chen, Hongguang Du, Jiaxi Xu, Zhanhui Yang · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c01067 · 被引用次数：10 · 研究领域：Sulfur-Based Synthesis Techniques、Synthesis and Catalytic Reactions、Cyclopropane Reaction Mechanisms

By leveraging the Rh-catalyzed asymmetric skeletal editing of 1,2,3-thiadiazoles, we successfully achieve the ligand-controlled enantioselective and regiodivergent synthesis of structurally diverse 2- and 3-alkylidene 2,3-dihydrothiophenes. Late-stage structural editing of complex natural and drug molecules is also enabled.