Associations between skeletal muscle strength and chronic kidney disease in patients with MASLD

作者：Xinlei Zhang, Yeqing Gu, Jing Zhao, Pei‐Wu Zhu, Wen‐Ying Chen, Gang Li, Wen‐Yue Liu, Wen Zheng, Ni Zhang, Lili Chen, Giovanni Targher, Christopher D. Byrne, Kaijun Niu, Dan‐Qin Sun, Ming‐Hua Zheng · 发表于：Communications Medicine · 年份：2025 · DOI：10.1038/s43856-025-00821-x · 被引用次数：7 · 研究领域：Nutrition and Health in Aging、Liver Disease Diagnosis and Treatment、Liver Disease and Transplantation

A skeletal muscle strength (SMS) decline is associated with metabolic diseases, but whether SMS also declines with chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) is uncertain. This study examined the associations between SMS and the risk of CKD in MASLD population. We performed a large-scale study with four cohorts: PERSONS and NHANES 2011–2014 cohorts for the cross-sectional investigation, and TCLSIH and UK Biobank cohorts for the longitudinal investigation. A handgrip dynamometer measured handgrip strength as a proxy for overall SMS. Participants were stratified according to CKD status [non-CKD vs. CKD (stages 1–5) groups]. In the PERSONS cohort, the CKD group has a lower handgrip strength than the non-CKD group (27.14 ± 9.19 vs. 33.59 ± 11.92 kg, P < 0.001). Higher handgrip strength is associated with lower odds of abnormal albuminuria or CKD (OR: 0.96, 95%CI:0.92-0.99 and OR:0.95, 95%CI: 0.91-0.99 respectively). The highest handgrip strength tertile is associated with the lowest risk of having abnormal albuminuria or CKD (compared with the lowest or middle tertile). Results are similar in NHANES cohort. Furthermore, the highest handgrip strength is independently associated with the lowest risk of incident CKD in MASLD (HR: 0.95, 95%CI: 0.92-0.99 and HR:0.99, 95%CI: 0.98-0.99 in TCLSIH and UK Biobank cohorts). In Kaplan-Meier curve analysis, the cumulative incidence of CKD is lowest in the highest handgrip ...