Association between the uric acid-to-HDL-cholesterol ratio (UHR) and the risk of cardiovascular disease and dyslipidemia: a population-based study

作者：Yanfeng Yi, Qin Luo, Jingfei Chen, Ze-Wei Chen, Hacı Ahmet Aydemir, Pengfei Chen, Jianjun Tang, Fei Luo, Zhenfei Fang · 发表于：Lipids in Health and Disease · 年份：2025 · DOI：10.1186/s12944-025-02551-4 · 被引用次数：28 · 研究领域：Gout, Hyperuricemia, Uric Acid、Diabetes, Cardiovascular Risks, and Lipoproteins、Thyroid Disorders and Treatments

BACKGROUND AND AIMS: The uric acid-to-HDL-cholesterol ratio (UHR), a novel marker of metabolism and inflammation, has been investigated in various diseases. However, its potential associations with the incidence of cardiovascular disease (CVD) and dyslipidemia remain unclear. This study aimed to examine the relationships between the UHR and the incidence of CVD and dyslipidemia. The primary objective was to evaluate the role of the UHR in predicting CVD and dyslipidemia, whereas the secondary objective was to analyze the predictive effects of the UHR in different subgroups. METHODS: We conducted a cross-sectional analysis using data from the 2001-2018 National Health and Nutrition Examination Survey (NHANES), which included 6,370 adults aged 18-80 years. Weighted binary logistic regression and subgroup analyses were performed to evaluate the independent associations between the UHR and the risk of various cardiovascular conditions, including overall CVD, congestive heart failure, myocardial infarction, angina, coronary heart disease, and dyslipidemia. To investigate potential nonlinear relationships between the UHR and these outcomes, restricted cubic spline modeling was applied to further elucidate the associations. RESULTS: Among the 6,370 participants included in the study, 559 were diagnosed with CVD. Elevated UHR values were strongly associated with a greater incidence of CVD and its subtypes, including congestive heart failure, myocardial infarction, angina, and coronar...