Cognitive Behavior Therapy for Mental Disorders in Adults

作者：Pim Cuijpers, Mathias Harrer, Clara Miguel, Markéta Čihařová, Davide Papola, Djordje Basic, Cristina Botella, Ioana A. Cristea, Nino de Ponti, Tara Donker, Ellen Driessen, Pamela Franco, Irene Gómez‐Gómez, Jessica L. Hamblen, Noelia Jiménez-Orenga, Eirini Karyotaki, Aaron Keshen, Jake Linardon, Emma Motrico, Minoo Matbouriahi, Olga M. Panagiotopoulou, Rory A. Pfund, Constantin Yves Plessen, Heleen Riper, Paula P. Schnurr, Marit Sijbrandij, Marieke B.J. Toffolo, Lingyao Tong, Wouter van Ballegooijen, Els van der Ven, Annemieke van Straten, Yingying Wang, Toshi A. Furukawa · 发表于：JAMA Psychiatry · 年份：2025 · DOI：10.1001/jamapsychiatry.2025.0482 · 被引用次数：58 · 研究领域：Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes、Personality Disorders and Psychopathology、Bipolar Disorder and Treatment

Importance: Cognitive behavior therapy (CBT) is a first-line treatment for most mental disorders. However, no meta-analytic study has yet integrated the results of randomized clinical trials on CBT across different disorders, using uniform methodologies and providing a complete overview of the field. Objective: To examine the effect sizes of CBT for 4 anxiety disorders, 2 eating disorders, major depression, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), and psychotic and bipolar disorders on symptoms of the respective disorders using uniform methodologies for data extraction, risk of bias (RoB) assessment, and meta-analytic techniques. Data Sources: Major bibliographical databases (PubMed, PsycINFO, and Embase for all disorders) were searched up to January 1, 2024, for each disorder separately. Data analysis was performed from August 2024 to January 2025. Study Selection: Randomized clinical trials comparing CBT with inactive control conditions in adults with 1 of the mental disorders established through a clinical interview were included. Data Extraction and Synthesis: Basic characteristics of patients, CBT, and studies were extracted. RoB was assessed with the Cochrane RoB tool 2. Meta-analyses were conducted using random-effects models. Main Outcomes and Measures: The primary outcome was the standardized mean difference (Hedges g) indicating the difference between CBT and controls at posttreatment on symptoms of the respective disorders. Results...