Associations between dietary fiber, the gut microbiota, and health outcomes in breast cancer survivors: A scoping review

作者：Elham Samami, Angela Starkweather, Debra Lyon, Debra Lynch Kelly · 发表于：Clinical Nutrition Open Science · 年份：2025 · DOI：10.1016/j.nutos.2025.03.012 · 被引用次数：3 · 研究领域：Nutrition and Health in Aging、Diet and metabolism studies、Nutritional Studies and Diet

Background Breast cancer (BC) is the most frequently identified malignancy in women and a major cause of female mortality. Its progression is influenced by a range of factors, including genetic, environmental, lifestyle, and hormonal elements. Recently, the gut microbiota (GM) has emerged as an important factor impacting BC. Dietary factors, particularly dietary fibers, may play a significant role in BC survivorship. These nondigestible carbohydrates serve as nutrients for gut microorganisms, promoting GM diversity and production of beneficial short-chain fatty acids (SCFAs), which possess anti-inflammatory and antiproliferative properties, influencing estrogen metabolism through the gut estrobolome, which modulates estrogen exposure and BC risk. This review synthesizes current literature on the effects of dietary fibers on GM in BC patients, exploring underlying mechanisms and clinical implications. Method Studies from PubMed/Medline and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were identified up to June 2024, including quantitative designs targeting BC cases with performed GM analyses. Results Ten studies met the inclusion criteria, revealing that dietary fibers consistently correlate with beneficial changes in GM, such as increased diversity and beneficial bacterial abundance while reducing harmful bacteria linked to estrogen reabsorption. Dietary fibers influence GM by serving as fermentation substrates and producing SCFAs. Conclusions T...