All-natural aggregation-induced emission-active glycyrrhizic acid hydrogels for drug-resistant bacteria-infected wound healing

作者：Qing Li, Yang Liu, Sili Liu, Shiqi Zhang, Xinke Yu, Zhili Wan, Yuan Yang, Paul Van der Meeren, Xiaoquan Yang · 发表于：Chemical Engineering Journal · 年份：2025 · DOI：10.1016/j.cej.2025.162677 · 被引用次数：17 · 研究领域：Nanoplatforms for cancer theranostics、Antimicrobial Peptides and Activities、Advanced Drug Delivery Systems

Aggregation-induced emission-active (AIE-active) hydrogels with a unique integration of both luminescence behavior and gel properties have attracted increasing attention due to their advanced functionalities and applications. However, the development of biocompatible AIE-active hydrogels with superior luminescence performances and sufficient mechanical strength remains a big challenge in the biomedical field, and particularly, bioactive AIE hydrogels from naturally occurring small molecules are highly desirable for use as ideal dressings in clinical practice of infected wound healing, in terms of their strong intrinsic biological activities, good biocompatibility, as well as facile and environmentally friendly processes. Here, for the first time, we report an all-natural robust AIE-active hydrogel consisting of two natural Chinese herbal molecules, i.e. glycyrrhizic acid (GA) and berberine (BR), which can be developed as green dressings for accelerating methicillin-resistant Staphylococcus aureus (MRSA)-infected wound healing. This GN-BR hydrogel is constructed from the self-assembly of supramolecular GA nanofibrils (GN) as well as their interactions with BR molecules, leading to the formation of an aggregated fibrillar network embedded with the GN-BR particles, which endow the hydrogels with a strong fluorescence emission, excellent mechanical strength and structural recovery capacity, and interesting stimuli-responsive fluorescence features. More importantly, benefiting fro...