Global, regional, and national burden of leukemia, 1990–2021: a systematic analysis of the global burden of disease in 2021

作者：Jiaxi Chen, Wenyi Pang, Miao Deng, Rubin Zheng, Yanjin Chen, Ziyang Zhang, Zhouke Tan, Zhixun Bai · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1542317 · 被引用次数：14 · 研究领域：Acute Lymphoblastic Leukemia research、Childhood Cancer Survivors' Quality of Life、Acute Myeloid Leukemia Research

Background: Leukemia is a heterogeneous hematologic malignancy with varying incidence, mortality, and disability-adjusted life years (DALYs) worldwide. Although the burden of leukemia has declined over recent decades, substantial disparities remain across different regions, socioeconomic levels, age groups, and sexes. This study looks at trends in leukemia cases, deaths, and the impact on quality of life from 1990 to 2021, aiming to uncover inequalities and help design better interventions. Methods: This study extracted data from the Global Burden of Disease (GBD) database (1990-2021) for five types of leukemia. The age-standardized incidence, mortality, and DALY rates for leukemia were calculated for 204 countries and 27 super regions worldwide. The estimated annual percentage change (EAPC) was used to quantify the trends in the leukemia burden, and trends were quantified using estimated annual percentage changes (EAPCs). Decomposition analysis examined the contributions of population growth, aging, and epidemiological changes. Additionally, autoregressive integrated moving average (ARIMA) and age-period-cohort (APC) models were employed. Inequality in leukemia burden was assessed using the Slope Index of Inequality (SII) and Concentration Index (CI). Results: Globally, the incidence and mortality of leukemia increased with age and were consistently higher in males. While incidence and mortality are projected to rise, DALYs are expected to decline slightly by 2031. Acute lym...