Stimuli-responsive peptide-based nanodrug delivery systems for tumor therapy

作者：Lei Zhou, Tingjie Zhang, Lu Zhang, Qiu-Ying Deng, Zhiyu Xia, Silin Chen, Dong‐Bing Cheng, Zeng‐Ying Qiao, Hao Wang · 发表于：Chemical Communications · 年份：2025 · DOI：10.1039/d5cc00950b · 被引用次数：10 · 研究领域：RNA Interference and Gene Delivery、Supramolecular Self-Assembly in Materials、Nanoparticle-Based Drug Delivery

toxicity. Peptide-based drug delivery systems have garnered significant attention due to the advantageous properties of peptides, including their excellent biocompatibility, diverse side-chain functionalities, and ability to form stable secondary structures. Incorporating stimuli-responsive amino acid residues or specific responsive moieties within their side chains endows these peptide-based drug delivery systems with unique stimuli-responsive characteristics. In this review, we summarize recent advancements and mechanisms in peptide-based nanodrug delivery systems that are capable of responding to one or multiple stimuli as well as conclude with a concise overview of the challenges that lie ahead in this field.